Cancer cells rewire metabolism to meet biosynthetic and energetic demands.The characteristic increase in glycolysis, i.e., Warburg effect, now considered as a hallmark, supports Self Tanning cancer in various ways.To attain such metabolic reshuffle, cancer cells preferentially re-express the M2 isoform of pyruvate kinase (PKM2, M2-PK) and alter its
The presence of single nucleotide variations in the coding region of micro-RNA (miRNA)-encoding genes plays a significant role in the expression and function of these molecules in oncogenesis and cancer.The association of rs2682818 in miR-618 with increased risk of breast cancer was investigated in the Iranian population.rs2682818/miR-618 was genot
Collective cell migration plays an important role in development.Here, we study the posterior lateral line primordium (PLLP) a group of about 100 cells, destined to form sensory structures, that migrates from head to tail in the Spring Pulley zebrafish embryo.We model mutually inhibitory FGF-Wnt signalling network in the PLLP and link tissue subdiv
In this post-genomic era, genome-wide functional analysis is indispensable.The recent development of RNA interference techniques has enabled researchers to easily analyze gene function Self Tanning even in non-model organisms.On the other hand, little progress has been made in the identification and functional analyses of cis-regulatory elements in
The nomination policy of Bongo local parliament members in general election is regulated in various policies by the Central Parliament, the President and the Election Commission.In order to improve the election quality, policy evaluation is required.This study uses legal research/normative methods and library/documentary study of the policies conte